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Ophthalmology Management | Glaucoma Minute

November 2015

What Is Plateau Iris?

Dr. Nathan M. Radcliffe

Plateau iris is defined as persistent iridotrabecular apposition after the placement of a peripheral iridotomy. On clinical examination, the anterior chamber may be deeper than is usual in angle-closure, and a characteristic “double hump sign” is seen on gonioscopy, with the proximal hump being due to the lens rise, and the distal hump being caused by the underlying and anteriorly located ciliary body. Plateau iris has the following characteristic findings on ultrasound biomicroscopy: an absent iridociliary sulcus, an anteriorly located ciliary body, and a centrally flat iris plane that is steep and narrow in the periphery where iridotrabecular contact is seen.1
 
In general, plateau iris is found in 32% of primary angle-closure suspect eyes that undergo peripheral laser iridotomy.1 Plateau iris tends to occur in younger people, it tends to cluster in families, and it tends to occur more frequently in atypical angle-closure suspects (e.g., pseudophakic and nearsighted eyes).2-4 While a presumed diagnosis of plateau iris can be made clinically based upon persistent iridotrabecular trabecular apposition (not synechiae) after laser iridotomy, ultrasound biomicroscopy is ideally suited to confirm the diagnosis.
 
What is one to do when the angle remains closed after the placement of a laser iridotomy in the plateau iris? If the intraocular pressure is normal, the optic nerve is healthy, and the visual field is full, I would argue that nothing should be done, other than routine monitoring.
 
Laser iridoplasty is the placement of peripheral iris contraction burns (lower power, large spot size, longer duration) with the intention of opening up the drainage angle in plateau iris. While the intent of laser iridoplasty is to pull the angle open by contracting the peripheral iris, it has been suggested that the angle opening is simply created by thinning of the peripheral iris stroma with the contraction burns.5
 
We do not have prospective randomized trials demonstrating the efficacy of peripheral iridoplasty, although a recent case series did suggest that, in markedly elevated intraocular pressures with the plateau iris, iridoplasty can be associated with significant intraocular pressure reduction.6
 
Laser iridoplasty is generally well tolerated, but can be associated with prolonged inflammation and even pupillary abnormalities, including Urrets-Zavalia.7 It is controversial whether cataract extraction opens the angle in plateau iris. It has been reported that it does not; however, in one study, the presence of plateau iris was associated with better intraocular pressure reduction after cataract extraction in angle closure.8,9
 
In summary, we have much to learn about plateau iris.

Reference(s): 1. Kumar RS, Baskaran M, Chew PT, et al. Prevalence of plateau iris in primary angle closure suspects an ultrasound biomicroscopy study. Ophthalmology. 2008;115:430-434.
2. Ritch R, Dorairaj S. Plateau iris syndrome in younger patients. Clin Experiment Ophthalmol. 2007 Jul;35(5):399-400.
3. Etter JR, Affel EL, Rhee DJ. High prevalence of plateau iris configuration in family members of patients with plateau iris syndrome. J Glaucoma. 2006 Oct;15(5):394-398.
4. Barkana Y, Shihadeh W, Oliveira C, Tello C, Liebmann JM, Ritch R. Angle closure in highly myopic eyes. Ophthalmology. 2006 Feb;113(2):247-254.
5. Liu J, Lamba T, Belyea DA. Peripheral laser iridoplasty opens angle in plateau iris by thinning the cross-sectional tissues. Clin Ophthalmol. 2013;7:1895-1897.
6. Ramakrishnan R, Mitra A, Abdul Kader M, Das S. To Study the Efficacy of Laser Peripheral Iridoplasty in the Treatment of Eyes With Primary Angle Closure and Plateau Iris Syndrome, Unresponsive to Laser Peripheral Iridotomy, Using Anterior-Segment OCT as a Tool. J Glaucoma. 2015 Sep 14. [Epub ahead of print]
7. Espana EM, Ioannidis A, Tello C, Liebmann JM, Foster P, Ritch R. Urrets-Zavalia syndrome as a complication of argon laser peripheral iridoplasty. Br J Ophthalmol. 2007 Apr;91(4):427-429.
8. Tran HV, Liebmann JM, Ritch R. Iridociliary apposition in plateau iris syndrome persists after cataract extraction. Am J Ophthalmol. 2003 Jan;135(1):40-43.
9. Tham CC, Leung DY, Kwong YY, et al. Factors correlating with failure to control intraocular pressure in primary angle-closure glaucoma eyes with coexisting cataract treated by phacoemulsification or combined phacotrabeculectomy. Asia Pac J Ophthalmol (Phila). 2015 Jan-Feb;4(1):56-59.

Dr. Nathan M. Radcliffe is the director of the glaucoma service and a clinical assistant professor at New York Univeristy Langone Ophthalmology Associates and is a cataract and glaucoma surgeon at the New York Eye Surgery Center.

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